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SleepCycle

60 capsules
by Tango Advanced Nutrition

Categories: Chinese Formulas, Sleep support
Retail Price: $39.95, Special Sales Price: $33.50 (You save 16%!)
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What is it?

SleepCycle contains in each capsule:

L-Theanine 200 mg
Melatonin 0.6 mg
5-HTP (5-Hydroxytryptophan) 50 mg

Proprietary Blend 750 mg:

Dang Quai root (Radix Angelicae Sinensis) Dang Gui
Hops fruit (Humulus Lupulus)
Lemon Balm aerial (Melissa officinalis)
Passionflower aerial (Passiflora incarnate)
Polygala root (Radix Polygalae Tenuifoliae) Yuan Zhi
Valerian root (Valeriana officinalis)
Wulinshen mycelia (Xylaria Nigripes) Wu Lin Shen
Jujube seed (Semen Ziziphi Spinosae) Suan Zao Ren

According to the manufacturer:

"SleepCycle® is an advanced, all-natural supplement offering a comprehensive approach to promoting healthy sleep patterns. SleepCycle achieves this by combining traditional herbal extracts with state-of-the-art modern nutrients for a unique, safe and effective natural sleep formula to aid in controlling restlessness and occasional sleeplessness. SleepCycle provides melatonin and 5-HTP, two nutritional compounds that have been shown to help initiate the natural process of falling asleep and promote normal sleep rhythms.

SleepCycle also contains a well-known combination of natural plant extracts that have been used for centuries to promote deep, restful sleep, including Hops, Lemon balm, Passionflower, Valerian root, Angelica, Jujube, and Polygala. Additionally, SleepCycle contains L-Theanine, an amino acid derived from green tea prized for its ability to promote calm and relax the mind.

Finally, SleepCycle contains a new, clinically researched herbal ingredient, Wulinshen, that is derived from the traditional herb, Xylaria Nigripes, by way of a proprietary extraction and formulation process. This proprietary compound, found only in SleepCycle, provides often depleted nutrients required by the brain to assist biochemical processes involved in promoting restful, deep sleep.

Wulinshen contains glutamic acid, gamma-aminobutyric acid (GABA) and glutamate decarboxylase. GABA's main function is to help regulate excitatory neuro-activities by exerting a tranquilizing effect on the central nervous system. Glutamate decarboxylase (GAD) supports the synthesis of GABA, while glutamic acid assists the uptake of GABA to specific brain cell receptors.

"SleepCycle is an advanced, all-natural supplement offering a comprehensive approach to maintaining healthy sleep patterns. SleepCycle achieves this by combining traditional herbal extracts with state-of-the-art modern nutrients for a unique, safe and effective natural sleep formula to aid in controlling restlessness and occasional sleeplessness.

Age-Related Sleep Problems

One of the biggest problems facing adults is the inability to achieve a deep, restful sleep, and by age 64 about half of all adults report some form of sleeping issue. (1) Age-related sleep issues have been linked to biochemical changes in the body's internal clock that alter the normal response to external light cues (i.e. sunset, sunrise). This results in older people going to sleep earlier in the evening and waking up earlier in the morning. Older sleepers also tend to wake up more frequently during the night, resulting in fragmented sleep.

SleepCycle for a Deeper Night's Sleep

Though people frequently tend to focus on falling asleep quickly, a far better indicator of sleep quality is the ability to wake up feeling refreshed, energized and restored the following day. Consequently, SleepCycle is not intended to act like a fast-acting sleeping pill that knocks people out quickly. Instead, SleepCycle works by gently promoting a state of calm as it initiates the natural process of falling asleep. Over time, SleepCycle conditions and maintains the overall quality of sleep by gradually extending the duration of deep, Slow Wave Sleep (SWS) and shortening the length of time it takes to fall into a restful slumber. SleepCycle achieves this by combining traditional herbal extracts with state-of-the-art modern nutrients to deliver a unique, safe and highly effective natural sleep aid.

SleepCycle Ingredients

SleepCycle begins with two nutritional compounds, melatonin and 5-HTP, that have been shown to support resynchronization of the body's biological clock to promote healthier sleep rhythms. SleepCycle also contains L-Theanine, an amino acid derived from green tea prized for its ability to maintain calm and relax the mind.

• L-Theanine
L-Theanine has been shown to regulate psychological and physiological stress responses, support cognitive performance, and relax the mind without inducing drowsiness. In research, L-Theanine intake resulted in a reduction in heart rate (HR) and salivary immunoglobulin A (s-IgA) responses to an acute stress task, which, say study authors, was attributable to an attenuation of sympathetic nervous activation. Thus, it was suggested that the oral intake of L-Theanine could cause such beneficial effects via inhibition of cortical neuron excitation. (2,3)

• Melatonin
Melatonin, the hormone produced nocturnally by the pineal gland, serves as a circadian time cue and sleep-anticipating signal in humans. With age, melatonin production declines as the prevalence of sleep issues increases. In one study melatonin was shown to exert significant and clinically meaningful improvements in sleep quality, morning alertness, sleep onset latency and quality of life in patients aged 55 years and over. (4)

• 5-HTP (5-Hydroxytryptophan)
An extract of the seed of the griffonia plant, 5-HTP is a necessary component for making serotonin in the body. Low levels of 5-HTP are associated with occasional sleeplessness and anxiety. In rats, 5-HTP was shown to alter sleep and brain temperature. (5)

Proprietary Herbal Blend with Wulinshen (Xylaria Nigripes)

SleepCycle contains a well-known combination of natural plant extracts that have been used for centuries to maintain deep, restful sleep, including Hops, Lemon Balm, Passionflower, Valerian root, Angelica sinensis, Jujube, and Polygala. These medicinal plants are traditionally endowed with relaxation and sleep-supporting properties.

• Tang-Kuei root (Dong Quai, Radix Angelicae Sinensis)
Traditionally used as a sleep aid, Tang-Kuei has been used safely for centuries in traditional Chinese medicine.

• Hops (Humulus Lupulus)
Hops has been used traditionally as a herbal remedy for sleep issues. Its effects in studies can be attributed to three categories of constituents of lipophilic hops extracts. Though the alpha-bitter acids proved to be the most active constituents, the beta-bitter acids and the hop oil clearly contributed to the activity of lipophilic Humulus extracts. (6)

• Lemon Balm (Melissa officinalis)
A novel pharmacological mechanism of action for the anxiety-modulating botanical Melissa officinalis L. (lemon balm) has been reported, and identified as a potent in vitro inhibitor of rat brain GABA transaminase (GABA-T). (7)

• Passionflower (Passiflora incarnate)
Passiflora incarnata has been used in sleep-support formulas for many centuries, and administration of oral Passiflora incarnata has been shown to aid in modulating anxiety. (8)

• Polygala (Radix Polygalae Tenuifoliae)
Polygala tenuifolia, an herbal ingredient found in traditional Asian sleep formulas, possesses several components, including 4,5-trimethoxycinnamic acid.(9) Study results indicate that the effects of Polygala in stressed animals might relate to its modulating effects on the hypothalamic-pituitary-adrenal (HPA) axis. (10)

• Valerian (Valeriana officinalis)
Valerian has an adenosine-like action and supports the readiness to fall asleep. Its action is closely related to endogenous melatonin secretion.(11) In studies, extracts of valerian demonstrate positive effects on sleep structure and sleep perception. (12)

• Jujube (Suan Zao Ren, Ziziphus jujuba var. spinosa)
Semen Ziziphus jujube (SZJ), the seeds of Ziziphus jujuba Mill. var. spinosa, is widely used in Chinese traditional medicine for sleep and relaxation, with studies showing that it exerts an inhibitory effect on glutamate (Glu) mediated excitatory signal pathways in the hippocampus. (13)

• Wulinshen (Xylaria Nigripes)
Wulinshen contains significant amounts of glutamic acid, gamma-aminobutyric acid (GABA) and glutamate decarboxylase. GABA's main function is to inhibit excitatory neuro-activities by exerting a sleep-promoting effect on the central nervous system. Glutamate decarboxylase (GAD) supports the synthesis of GABA, while glutamic acid assists the uptake of GABA to specific brain cell receptors.

Nine known compounds were isolated and identified in Xylaria nigripes for the first time, and their structures were mainly determined by MS and NMR methods. These include (1) 5-hydroxy-7-methoxy-2-methyl-4-chromanone, (2) 5,7-dihydroxy-2-methyl-4-chromanone, (3) 5-hydroxyl-2-methyl-4-chromanone, (4) 1-(2,6-dihydroxyphenyl)-3-hydroxybutanone, (5) 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol, (6) (22E,24R)-ergost-7,22-dien-3beta, 5alpha,6alpha-triol, (7) euphorbol, (8) beta-sitosterol and (9) 2-(4-hydroxyphenyl)-ethanol. (14)

Sleep Loss in Middle Age

In the first study of its kind, sleep researchers at the University of Pittsburgh found that the quality and duration of sleep changed dramatically between the mid-20s and the mid-50s, with subjects going to bed and waking up earlier. The subjects also slept less, woke up more often during the night, and experienced fewer stages of deep sleep. (15) According to study author, Dr. Julie Carrier, Middle age is a turning point for sleep. Some sleep patterns have already changed significantly by the time an average adult reaches age 30. Dr. Carrier observed that these changes are most likely tied to gradual age-related changes in features of the biological clock.

Research has already shown how disrupted sleep patterns are linked to significant age-related alterations in melatonin, the principal sleep hormone produced by the pineal gland. Melatonin levels are known to drop significantly after childhood and serve as one of the most dramatic markers of biological aging known. By the age of 60, nighttime melatonin production practically ceases, and by age 80, melatonin plasma levels are barely detectable.

Summary
SleepCycle is an advanced, all-natural supplement that offers a comprehensive approach to maintaining healthy sleep patterns. Unlike conventional sleeping aids that are designed to just put people to sleep quickly, SleepCycle targets each phase of human sleep with nutrients and plant compounds that have been shown to gently support the quality and duration of deep, restorative sleep, aiding the body in recovering from daily physical and mental stresses.

Cautions

We do not recommend that a woman take Sleep Cycle if she is pregnant or nursing. This is not because Sleep Cycle is unsafe but because there have been no safety studies performed on the ingredients in Sleep Cycle for pregnancy and nursing.

Sleep Cycle is not recommended for people under the age of 18.

See Disclaimer.

Suggested Use

The recommended daily dose of Sleep Cycle is 1-2 capsules, 1 time per day, 1 hour before bedtime.

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